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Anwulignan
| Product Name | Anwulignan |
| Price: | Inquiry |
| Catalog No.: | CN02943 |
| CAS No.: | 107534-93-0 |
| Molecular Formula: | C20H24O4 |
| Molecular Weight: | 328.41 g/mol |
| Purity: | >=98% |
| Type of Compound: | Lignans |
| Physical Desc.: | Powder |
| Source: | The fruits of Schisandra sphenanthera. |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | COc1cc(ccc1O)C[C@@H]([C@@H](Cc1ccc2c(c1)OCO2)C)C |
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| Description | Macelignan(Anwuligan) is a natural compound isolated from Myristica fragrans Houtt; possesses therapeutic potentials against neurodegenerative diseases with oxidative stress and neuroinflammation.IC50 value:Target: in vitro: Macelignan significantly attenuated the ROS production and neurotoxicity induced by glutamate in HT22 cell [1]. At 24 h of biofilm growth, S. mutans, A. viscosus and S. sanguis biofilms were reduced by up to 30%, 30% and 38%, respectively, after treatment with 10 microg/mL macelignan for 5 min [2]. Cisplatin-induced phosphorylation of c-Jun N-terminal kinase1/2 (JNK1/2) and extracellular signal-regulated kinase1/2 (ERK1/2) was abrogated by pretreatment with macelignan, however, that of p38 was not significantly affected [3].in vivo: Macelignan attenuated the expression of phosphorylated c-Jun in cisplatin-treated mice [3]. Daily administration of macelignan reduced the spatial memory impairments induced by the chronic LPS infusions [4]. |
| Density | 1.159 |
| Boiling Point | 467.0±40.0 °C at 760 mmHg |
| Flash Point | 236℃ |
| Exact Mass | 328.167450 |
| PSA | 47.92000 |
| LogP | 5.22 |
| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
| Storage condition | -20°C |