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Ilexgenin A
| Product Name | Ilexgenin A |
| Price: | $293 / 10mg |
| Catalog No.: | CN07286 |
| CAS No.: | 108524-94-3 |
| Molecular Formula: | C30H46O6 |
| Molecular Weight: | 502.69 g/mol |
| Purity: | >=98% |
| Type of Compound: | Triterpenoids |
| Physical Desc.: | Powder |
| Source: | The roots of Ilex pubescens Hook.et Arn. |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | OC(=O)[C@]1(C)[C@@H](O)CC[C@]2([C@H]1CC[C@@]1([C@@H]2CC=C2[C@@]1(C)CC[C@@]1([C@H]2[C@](C)(O)[C@@H](CC1)C)C(=O)O)C)C |
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| Description | Ilexgenin A is a pentacyclic triterpenoid, which extracted from Ilex hainanensis Merr. Ilexgenin A can be used for the research of inflammation and cancer[1]. |
| In Vitro | Ilexgenin A (0~100 μM; 24 hours; HT 29 and HCT 116 cells) effectively decreases cell viability in HT 29 and HCT 116 cells[1]. Ilexgenin A (12.5~50 μM; 24 hours; HT 29 cells) downregulates the expression of SREBP-1, inhibits the translocation of SREBP-1 to the nucleus and decreases the content of TG[1]. Ilexgenin A (12.5~50 μM; HT 29 and HCT 116 cells) induces cell cycle arrest at G1 phase in colon cancer cells[1]. Ilexgenin A (12.5~50 μM; 24 hours; HCT 116 cells) modulates lipid metabolism. Ilexgenin A (50 μM; 24 hours; HT 29 and HCT 116 cells) regulates SREBP-1 by inhibiting HIF1α[1]. Ilexgenin A inhibits fatty acids synthesis[1]. Cell Viability Assay[1] Cell Line: HT 29 and HCT 116 cells Concentration: 0~100 μM Incubation Time: 24 hours Result: Effectively decreased cell viability in HT 29 and HCT 116 cells. Western Blot Analysis[1] Cell Line: HT 29 cells Concentration: 12.5~50 μM Incubation Time: 24 hours Result: Downregulated the expression of SREBP-1. RT-PCR[1] Cell Line: HT 29 cells Concentration: 12.5~50 μM Incubation Time: 24 hours Result: Decreased the content of TG. Immunofluorescence[1] Cell Line: HT 29 cells Concentration: 12.5~50 μM Incubation Time: 24 hours Result: Inhibited the translocation of SREBP-1 to the nucleus. |
| In Vivo | Ilexgenin A (20 mg/kg) ameliorates the AOM/DSS induced carcinogenesis. Ilexgenin A can regulate lipid metabolism. Ilexgenin A decreases the expression of SREBP-1 and HIF 1α in AOM/DSS mice[1]. |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 653.3±55.0 °C at 760 mmHg |
| Flash Point | 362.9±28.0 °C |
| Exact Mass | 502.329437 |
| LogP | 5.77 |
| Vapour Pressure | 0.0±4.4 mmHg at 25°C |
| Storage condition | 2-8℃ |