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Loureirin A
| Product Name | Loureirin A |
| Price: | $117 / 20mg |
| Catalog No.: | CN05652 |
| CAS No.: | 119425-89-7 |
| Molecular Formula: | C17H18O4 |
| Molecular Weight: | 286.3 g/mol |
| Purity: | >=98% |
| Type of Compound: | Chalcones |
| Physical Desc.: | Powder |
| Source: | The herbs of Dracaena cochinchinensis |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | COc1cc(OC)ccc1CCC(=O)c1ccc(cc1)O |
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| Description | Loureirin A is a flavonoid extracted from Dragon's Blood, can inhibit Akt phosphorylation, and has antiplatelet activity. |
| Target | Akt |
| In Vitro | Loureirin A (50 μM, 100 μM) inhibits collagen-induced platelet ATP secretion and thrombin-stimulated P-selectin expression in a dose-dependent manner. Loureirin A also significantly impairs platelet spreading on immobilized fibrinogen. Loureirin A almost completely eliminates collagen-induced Akt phosphorylation at Ser473 at the dose of 100 μM, and has an additive inhibitory effect with the phosphoinositide 3-kinase (PI3K) inhibitor Ly294002 on collage-induced Akt phosphorylation in platelets at 50 μM[1]. |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 479.1±40.0 °C at 760 mmHg |
| Flash Point | 175.8±20.8 °C |
| Exact Mass | 286.120514 |
| PSA | 55.76000 |
| LogP | 3.30 |
| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
| Storage condition | 2-8C |