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(-)-Epicatechin gallate
| Product Name | (-)-Epicatechin gallate |
| Price: | $31 / 20mg |
| Catalog No.: | CN05521 |
| CAS No.: | 1257-08-5 |
| Molecular Formula: | C22H18O10 |
| Molecular Weight: | 442.38 g/mol |
| Purity: | >=98% |
| Type of Compound: | Flavonoids |
| Physical Desc.: | White powder |
| Source: | The woods of Acacia catechu (L.F.) Willd. |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | Oc1cc(O)c2c(c1)O[C@@H]([C@@H](C2)OC(=O)c1cc(O)c(c(c1)O)O)c1ccc(c(c1)O)O |
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| Description | Epicatechin gallate inhibits cyclooxygenase-1 (COX-1) with an IC50 of 7.5 μM. |
| Target | COX-1:7.5 μM (IC50) |
| In Vitro | Epicatechin gallate exhibits >95% inhibitory activity at 70 μg/mL against cyclooxygenase-1 (COX-1) with an IC50 of 7.5 μM[1]. |
| In Vivo | Epicatechin gallate ((-)-Epicatechin-3-O-gallate, ECG), a component of Rhei Rhizoma, is one of the active components of Onpi-to, a herbal medicine composed of five crude drugs (Rhei Rhizome, Glycyrrhizae Radix, Ginseng Radix, Zingiberis Rhizoma and Aconiti Tuber). Following intravenous injection of Epicatechin gallate (1.0 mg/kg) in rats, the plasma concentration vs. time curve is fitted in a three compartment model. Pharmacokinetic parameters for plasma Epicatechin gallate (ECG) are measured. ECG has a t1/2α of 0.038 h, a t1/2βof 0.291 h and a t1/2γ of 4.033 h . The CLtot of ECG is 4.19 L/h • kg. The Vdss is 12.39 L/kg[2]. |
| Animal Admin | Rats[2] Male Sprague-Dawley rats, obtained at 7 weeks of age (210-245 g) are used. Epicatechin gallate (ECG) is suspended in 0.5% w/v sodium carboxymethylcellulose at 12.5, 25.0 and 50.0 mg/10 mL for oral administration to rats at 10 mL/kg. For intravenous injection in rats at 1.0 mg/kg, an ethanolic solution of Epicatechin gallate is diluted with 10% w/v sodium citrate solution to 1.0 mg/mL; the final concentration of ethanol is 1% v/v[2]. |
| Density | 1.8±0.1 g/cm3 |
| Boiling Point | 861.7±65.0 °C at 760 mmHg |
| Flash Point | 305.0±27.8 °C |
| Exact Mass | 442.089996 |
| PSA | 177.14000 |
| LogP | 2.67 |
| Vapour Pressure | 0.0±0.3 mmHg at 25°C |
| Storage condition | 2-8°C |