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Crosstide
| Product Name | Crosstide |
| Price: | Inquiry |
| Catalog No.: | CN00046 |
| CAS No.: | 171783-05-4 |
| Molecular Formula: | C48H77N17O17 |
| Molecular Weight: | 1164.2 g/mol |
| Purity: | >=98% |
| Type of Compound: | Alkaloids |
| Physical Desc.: | Powder |
| Source: | |
| Solvent: | DMSO, Pyridine, Methanol, Ethanol, etc. |
| SMILES: |
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| Description | Crosstide is a peptide analog of glycogen synthase kinase α/β fusion protein sequence which is a substrate for Akt. |
| Target | Akt |
| In Vitro | 16HBE14o− cells exposed to RV39 demonstrate a crosstide kinase activity in vitro. Serine phosphorylation of crosstide is confirmed by immunoblotting, and phosphorylation is blocked by PP2 but not by PP3[1]. The wildtype GST-AKT2 shows significant phosphoryl transferase activity towards crosstide, reaching an initial velocity of 16 pmol phosphate/min/μg enzyme. The mutant GST-AKT2T/E,S/D displayed an initial velocity of 85 pmol phosphate/min/μg kinase for phosphorylation of Crosstide, corresponding to a 5-fold increase compared to the wildtype enzyme[2]. |
| Density | 1.6±0.1 g/cm3 |
| Exact Mass | 1163.568359 |
| LogP | -4.77 |
| Storage condition | 2-8℃ |