Home
Products
(S)-10-Hydroxycamptothecin
| Product Name | (S)-10-Hydroxycamptothecin |
| Price: | $23 / 20mg |
| Catalog No.: | CN02165 |
| CAS No.: | 19685-09-7 |
| Molecular Formula: | C20H16N2O5 |
| Molecular Weight: | 364.35 g/mol |
| Purity: | >=98% |
| Type of Compound: | Alkaloids |
| Physical Desc.: | Powder |
| Source: | The barks of Camptotheca acuminata Decne. |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | CC[C@@]1(O)C(=O)OCc2c1cc1c3nc4ccc(cc4cc3Cn1c2=O)O |
| Contact us | |
|---|---|
| First Name: | |
| Last Name: | |
| E-mail: | |
| Question: | |
| Description | (S)-10-Hydroxycamptothecin is a clinical therapy agent against hepatoma.IC50 value:Target:In vitro: In vitro, the 10-hydroxycamptothecin nanosuspensions released the encapsulated drug with nearly zero-order kinetics, and the accumulative release reached 90% within 72 hours. In vitro cytotoxicity assay showed that the 10-hydroxycamptothecin nanosuspensions had significantly enhanced cytotoxicity against HepG2 cells compared to the commercially available 10-hydroxycamptothecin injections [1].In vivo: The in vivo study with H22 tumor-bearing mice and intravenous injection of the drug showed that in contrast to the 10-hydroxycamptothecin injections, the 10-hydroxycamptothecin nanosuspensions exhibited significantly enhanced biodistribution, particularly in the lung (393.40-fold AUC0–24 h, liver (192.35-fold AUC0–24 h, spleen (141.67-fold AUC0–24 h and tumor (64.21-fold AUC0–24 h. The 10-hydroxycamptothecin nanosuspensions also showed improved antitumor therapeutic efficacy over the injections (89.83% vs. 30.56%) [1]. |
| Density | 1.6±0.1 g/cm3 |
| Boiling Point | 820.7±65.0 °C at 760 mmHg |
| Flash Point | 450.1±34.3 °C |
| Exact Mass | 364.105927 |
| PSA | 101.65000 |
| LogP | 1.32 |
| Vapour Pressure | 0.0±3.1 mmHg at 25°C |
| Storage condition | -20°C Freezer |