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L-Menthol
| Product Name | L-Menthol |
| Price: | $15 / 20mg |
| Catalog No.: | CN09678 |
| CAS No.: | 2216-51-5 |
| Molecular Formula: | C10H20O |
| Molecular Weight: | 156.27 g/mol |
| Purity: | >=98% |
| Type of Compound: | Monoterpenoids |
| Physical Desc.: | Cryst. |
| Source: | The herbs of Mentha canadensis L. |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | C[C@@H]1CC[C@H]([C@@H](C1)O)C(C)C |
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| Description | (-)-Menthol is a key component of peppermint oil that binds and activates transient receptor potential melastatin 8 (TRPM8), a Ca2+-permeable nonselective cation channel, to increase [Ca2+]i[1]. Antitumor activity[1]. |
| Target | TRPM8[1] |
| In Vitro | (-)-Menthol (Menthol ) per se does not exhibit antiproliferative activity, but it is able to enhance 1α,25(OH)2D3-mediated growth inhibition in LNCaP cells. At high (-)-Menthol concentrations above 1.6 mM, the cells begin to detach from the culture dish[1]. (-)-Menthol (0.8 mM) can increase [Ca2+]i via transmembrane influx or store release pathways. Peak increase in [Ca2+]i was 102.3±39 nM (n=3) in (-)-Menthol alone and 124.5±51 nM (n=3) in combination of 1α,25(OH)2D3 with (-)-Menthol, respectively[1]. Combination of 1α,25(OH)2D3 with (-)-Menthol (0.8 mM) cooperatively modulates bcl-2 and p21 expression[1]. |
| Density | 0.9±0.1 g/cm3 |
| Boiling Point | 215.4±8.0 °C at 760 mmHg |
| Flash Point | 93.3±0.0 °C |
| Exact Mass | 156.151413 |
| PSA | 20.23000 |
| LogP | 3.20 |
| Vapour Pressure | 0.0±0.9 mmHg at 25°C |