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T0070907
| Product Name | T0070907 |
| Price: | Inquiry |
| Catalog No.: | CN00422 |
| CAS No.: | 313516-66-4 |
| Molecular Formula: | C12H8ClN3O3 |
| Molecular Weight: | 277.66 g/mol |
| Purity: | >=98% |
| Type of Compound: | Alkaloids |
| Physical Desc.: | Powder |
| Source: | |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | Clc1ccc(cc1C(=O)Nc1ccncc1)[N+](=O)[O-] |
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| Description | T0070907 is a potent PPARγ antagonist with a Ki of 1 nM. |
| Target | PPARγ:1 nM (Ki) PPARδ:1.8 μM (Ki) PPARα:0.85 μM (Ki) |
| In Vitro | T0070907 (50 μM) pre-treatment impairs repair of IR-induced DNA DSBs in both ME-180 and SiHa cells treated with irradiated (4 Gy). T0070907 (0-50 μM) significantly decreases the levels of DNA-PKcs and RAD51 proteins in ME-180 and SiHa cells[1]. T0070907 (50 μM) treatment reduces the levels of α- and β-tubulin protein in a time-dependent manner, decreases the synthesis of DNA, and prevents the radiation-induced alterations in the cell cycle regulatory proteins of ME180 and SiHa cells[2]. T0070907 (10 µM) has cytotoxicity in an adipocyte-specific and PPARγ-independent manner. T0070907 increases oxidative stress in immature adipocytes[3]. T0070907 (1 μM) blocks the induction of adipogenesis by various treatments of the adipogenic cell line 3T3-L1. T0070907 covalently modifies PPAR on cysteine 313 in helix 3 of human PPAR 2[4]. |
| Density | 1.5±0.1 g/cm3 |
| Boiling Point | 381.7±37.0 °C at 760 mmHg |
| Flash Point | 184.6±26.5 °C |
| Exact Mass | 277.025421 |
| PSA | 87.81000 |
| LogP | 2.25 |
| Vapour Pressure | 0.0±0.9 mmHg at 25°C |
| Storage condition | Store at RT |