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Kuraridine
| Product Name | Kuraridine |
| Price: | Inquiry |
| Catalog No.: | CN05662 |
| CAS No.: | 34981-25-4 |
| Molecular Formula: | C26H30O6 |
| Molecular Weight: | 438.5 g/mol |
| Purity: | >=98% |
| Type of Compound: | Chalcones |
| Physical Desc.: | Yellow powder |
| Source: | The roots of Sophora flavescens |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: |
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| Description | Kuraridine is a prenylated flavonol extract from the roots of Sophora flavescens. Kuraridine an inhibitory effect on cGMP specific phosphodiesterase type 5 (PDE5) and has an IC50 of 0.64 μM[1]. |
| Target | PDE5:0.64 μM (IC50) |
| In Vitro | Kuraridine shows potent inhibitory activity (IC50=0.64 μM) against cGMP PDE5 with 2.0- and 12.9-fold selectivity over PDE3 and PDE4, respectively[1]. Kuraridine induces pronounced chloride inward currents in the absence of GABA. Thecurrents does not exceed 10% of the maximal IGABA induced by a saturating GABA concentration (1 mM)[2]. Kuraridine induces a concentration–response curves for IGABA enhancement (EC50=4.0±2.4 μM) in Xenopus oocytes expressing GABAA receptors composed of α1, β2, and γ2S subunits[2]. |
| Exact Mass | 438.20400 |
| PSA | 107.22000 |
| LogP | 5.50480 |