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Ziyuglycoside I
| Product Name | Ziyuglycoside I |
| Price: | $62 / 20mg |
| Catalog No.: | CN07955 |
| CAS No.: | 35286-58-9 |
| Molecular Formula: | C41H66O13 |
| Molecular Weight: | 767.0 g/mol |
| Purity: | >=98% |
| Type of Compound: | Triterpenoids |
| Physical Desc.: | White powder |
| Source: | The roots of Sanguisorba officinalis. |
| Solvent: | DMSO, Pyridine, Methanol, Ethanol, etc. |
| SMILES: | OCC1OC(OC(=O)C23CCC(C(C3C3=CCC4C(C3(CC2)C)(C)CCC2C4(C)CCC(C2(C)C)OC2OCC(C(C2O)O)O)(C)O)C)C(C(C1O)O)O |
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| Description | Ziyuglycoside I isolated from S. officinalis root, has anti-wrinkle activity, and increases the expression of type I collagen. Ziyuglycoside I could be used as an active ingredient for cosmetics[1].Ziyuglycoside I triggers cell cycle arrest and apoptosis mediated by p53, it can be a potential drug candidate for treating triple-negative breast cancer (TNBC)[2]. |
| In Vitro | Ziyuglycoside I (5-160 µM; 24 hours) reveals a marked anti-proliferation activity with an IC50 value of 13.96 µM in MDA-MB-231 cells[2]. Ziyuglycoside I (5-20 µM; 24 hours) induces MDA-MB-231 cell apoptosis by increasing the percentage of apoptotic cells from 2.43% to 44.76% at 20 µM[2]. Ziyuglycoside I (5-20 µM; 24 hours) induces the cleavage of caspas-8, caspase-9, and caspase-3, up-regulates the pro-apoptotic protein Bax, and down-regulates anti-apoptotic protein Bal-2, dose-dependently reduces the level of mito-cyto c expression[2]. Cell Viability Assay[1] Cell Line: MDA-MB-231 cells Concentration: 5 µM, 10 µM, 20 µM, 40 µM, 80 µM, and 160 µM Incubation Time: 24 hours Result: Showed cytotoxicity on MDA-MB-231 cells. Cell Cycle Analysis[1] Cell Line: MDA-MB-231 cells Concentration: 5 µM, 10 µM, and 20 µM Incubation Time: 24 hours Result: Induced G2/M phase arrest and apoptosis on MDA-MB-231 Cells Western Blot Analysis[1] Cell Line: MDA-MB-231 cells Concentration: 5 µM, 10 µM, and 20 µM Incubation Time: 24 hours Result: Induced apoptosis in MDA-MB-231 Cells through Intrinsic and Extrinsic Pathways. |
| Density | 1.35 |
| Boiling Point | 841.9±65.0 °C at 760 mmHg |
| Flash Point | 247.2±27.8 °C |
| Exact Mass | 766.450317 |
| PSA | 215.83000 |
| LogP | 6.59 |
| Vapour Pressure | 0.0±0.6 mmHg at 25°C |
| Storage condition | 2-8°C |