Home
Products
Ziyuglycoside II
| Product Name | Ziyuglycoside II |
| Price: | $103 / 20mg |
| Catalog No.: | CN07954 |
| CAS No.: | 35286-59-0 |
| Molecular Formula: | C35H56O8 |
| Molecular Weight: | 604.8 g/mol |
| Purity: | >=98% |
| Type of Compound: | Triterpenoids |
| Physical Desc.: | Powder |
| Source: | The roots of Sanguisorba officinalis. |
| Solvent: | DMSO, Pyridine, Methanol, Ethanol, etc. |
| SMILES: | OC1COC(C(C1O)O)OC1CCC2(C(C1(C)C)CCC1(C2CC=C2C1(C)CCC1(C2C(C)(O)C(C)CC1)C(=O)O)C)C |
| Contact us | |
|---|---|
| First Name: | |
| Last Name: | |
| E-mail: | |
| Question: | |
| Description | Ziyuglycoside II is a triterpenoid saponin compound extracted from Sanguisorba officinalis L.. Ziyuglycoside II induces reactive oxygen species (ROS) production and apoptosis. Anti-inflammation and anti-cancer effect[1]. |
| In Vitro | Ziyuglycoside II (10-60 μM; 24 h and 48 h) inhibits MDA-MB-435 cells growth in a dose-dependent manner. The IC50 of Ziyuglycoside II at 24 h and 48 h is 5.92 μM and 4.74 μM, respectively[1]. Ziyuglycoside II (5-25 μM) induces G0/G1 and S phase arrest in MDA-MB-435 cells at 24 h[1]. Ziyuglycoside II (5-25 μM; 24 hours) significantly increases apoptotic rate of MDA-MB-435 cells[1]. Ziyuglycoside II (5-25 μM; 24 hours) increases expressions of both p53 and p21 in MDA-MB-435 cells, which effect is dose-dependent[1]. Cell Viability Assay[1] Cell Line: MDA-MB-435 cells Concentration: 10, 20, 30, 40, 50, 60 μM Incubation Time: 24 hours and 48 hours Result: The IC50 at 24 h and 48 h was 5.92 μM and 4.74 μM, respectively. Cell Cycle Analysis[1] Cell Line: MDA-MB-435 cells Concentration: 5, 10, 25 μM Incubation Time: 24 hours Result: Induced G0/G1 and S phase arrest. Apoptosis Analysis[1] Cell Line: MDA-MB-435 cells Concentration: 5, 10, 25 μM Incubation Time: 24 hours Result: The apoptotic rate was significantly increased in comparison to that of the control. Western Blot Analysis[1] Cell Line: MDA-MB-435 cells Concentration: 5, 10, 25 μM Incubation Time: 24 hours Result: Treatment resulted in increased expressions of both p53 and p21. |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 716.2±60.0 °C at 760 mmHg |
| Flash Point | 218.6±26.4 °C |
| Exact Mass | 604.397522 |
| PSA | 136.68000 |
| LogP | 7.68 |
| Vapour Pressure | 0.0±5.2 mmHg at 25°C |
| Storage condition | 2-8°C |