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Nigranoic acid
| Product Name | Nigranoic acid |
| Price: | Inquiry |
| Catalog No.: | CN07762 |
| CAS No.: | 39111-07-4 |
| Molecular Formula: | C30H46O4 |
| Molecular Weight: | 470.69 g/mol |
| Purity: | >=98% |
| Type of Compound: | Triterpenoids |
| Physical Desc.: | Powder |
| Source: | The fruits of Schisandra chinensis |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: |
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| Description | Nigranoic acid is a triterpenoid separated from Schisandra chinensis. Nigranoic acid inhibits HIV-1 reverse transcriptase. Nigranoic acid exhibits protective effects on brain through PARP/AIF signaling pathway in cerebral ischemia-reperfusion animal model[1][2]. |
| Target | HIV-1 reverse transcriptase |
| In Vivo | Nigranoic acid has a strong protective effect on rat cerebral ischemia-reperfusion injury, and acts by downregulating nerve cell apoptosis by preventing the overactivation of PARP and AIF nuclear translocation[2]. Nigranoic acid (1 mg/kg; i.g.; 6 hours and 2 hours before brain ischemia) significantly decreases apoptosis and the expression levels of AIF protein, PARP protein, and AIF mRNA at different time-points[2]. Animal Model: Sprague–Dawley rats (200-300 g), ischemia–reperfusion model[2] Dosage: 1 mg/kg Administration: Intragastric; 6 hours and 2 hours before brain ischemia Result: Decreased apoptosis and the expression levels of AIF protein, PARP protein, and AIF mRNA at different time-points. |
| Exact Mass | 470.34000 |
| PSA | 74.60000 |
| LogP | 7.49360 |