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Taxifolin
| Product Name | Taxifolin |
| Price: | $18 / 20mg |
| Catalog No.: | CN05359 |
| CAS No.: | 480-18-2 |
| Molecular Formula: | C15H12O7 |
| Molecular Weight: | 304.3 g/mol |
| Purity: | >=98% |
| Type of Compound: | Flavonoids |
| Physical Desc.: | Powder |
| Source: | The barks of Pinus yunnanensis. |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | Oc1cc2O[C@H](c3ccc(c(c3)O)O)[C@H](C(=O)c2c(c1)O)O |
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| Description | Taxifolin exhibits important anti-tyrosinase activity. Taxifolin exhibits significant inhibitory activity against collagenase with an IC50 value of 193.3 μM. |
| Target | IC50: 193.3 μM (Collagenase)[1] Tyrosinase[1] |
| In Vitro | This is confirmed by the investigation of pure Taxifolin and (+)-Catechin against collagenase activity. Taxifolin exhibits significant inhibitory activity with an IC50 value of 193.3 μM while (+)-Catechin is not active[1]. Taxifolin is a ubiquitous bioactive constituent of foods and herbs. Taxifolin (dihydroquercetin) is a bioactive flavanonol commonly found in grapes, citrus fruits, onions, green tea, olive oil, wine, and many other foods, as well as several herbs (such as milk thistle, French maritime bark, Douglas fir bark, and Smilacis Glabrae Rhizoma)[2]. |
| In Vivo | Taxifolin may be easily metabolized and that its metabolites are the prevalent form in vivo, although limited information is available on metabolism of Taxifolin in vivo[2]. |
| Animal Admin | Rats[2] Twelve male Sprague-Dawley rats (weighing 180-220 g) are used. The rats are randomly divided into two groups (six rats per group), a drug group and a blank group. Taxifolin is suspended in 0.5% CMC-Na solution and orally administered to the drug group at a dose of 200 mg/kg body weight, while blank group rats are orally administered 0.5% CMC-Na solution at the same volume. All rats are dosed once a day (at 9:00 a.m.) for 3 days. |
| Density | 1.7±0.1 g/cm3 |
| Boiling Point | 687.6±55.0 °C at 760 mmHg |
| Flash Point | 264.2±25.0 °C |
| Exact Mass | 304.058289 |
| PSA | 127.45000 |
| LogP | 1.82 |
| Vapour Pressure | 0.0±2.3 mmHg at 25°C |
| Storage condition | -20?C Freezer |