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2,5-Dihydroxyacetophenone
| Product Name | 2,5-Dihydroxyacetophenone |
| Price: | Inquiry |
| Catalog No.: | CN03728 |
| CAS No.: | 490-78-8 |
| Molecular Formula: | C8H8O3 |
| Molecular Weight: | 152.2 g/mol |
| Purity: | >=98% |
| Type of Compound: | Phenols |
| Physical Desc.: | Powder |
| Source: | The fruits of Citrus maxima. |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | Oc1ccc(c(c1)C(=O)C)O |
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| Description | 2,5-Dihydroxyacetophenone, isolated from Rehmanniae Radix Preparata, inhibits the production of inflammatory mediators in activated macrophages by blocking the ERK1/2 and NF-κB signaling pathways[1]. |
| Target | ERK1 ERK2 NF-κB |
| In Vitro | 2,5-Dihydroxyacetophenone significantly inhibits NO production via the suppression of iNOS expression and significantly decreases levels of the pro-inflammatory cytokines TNF-α and IL-6 via the down-regulation of their mRNA expression in LPS-stimulated RAW264.7 cells. 2,5-Dihydroxyacetophenone potently inhibits the phosphorylation of extracellular signal-related kinase (ERK) 1/2 and the nuclear translocation of nuclear factor-κB (NF-κB) p65 in LPS-stimulated cells[1]. |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 329.2±27.0 °C at 760 mmHg |
| Flash Point | 167.1±20.2 °C |
| Exact Mass | 152.047348 |
| PSA | 57.53000 |
| LogP | 1.59 |
| Vapour Pressure | 0.0±0.7 mmHg at 25°C |