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Esculentoside A
| Product Name | Esculentoside A |
| Price: | $62 / 20mg |
| Catalog No.: | CN07971 |
| CAS No.: | 65497-07-6 |
| Molecular Formula: | C42H66O16 |
| Molecular Weight: | 826.96 g/mol |
| Purity: | >=98% |
| Type of Compound: | Triterpenoids |
| Physical Desc.: | White powder |
| Source: | The roots of Phytolacca acinosa Roxb |
| Solvent: | DMSO, Pyridine, Methanol, Ethanol, etc. |
| SMILES: | OC[C@H]1O[C@@H](O[C@@H]2CO[C@H]([C@@H]([C@H]2O)O)O[C@H]2[C@@H](O)C[C@]3([C@H]([C@]2(C)CO)CC[C@@]2([C@@H]3CC=C3[C@@]2(C)CC[C@@]2([C@H]3C[C@](C)(CC2)C(=O)OC)C(=O)O)C)C)[C@@H]([C@H]([C@@H]1O)O)O |
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| Description | Esculentoside A (EsA), a kind of triterpene saponin isolated from roots of Phytolacca esculenta[1].Esculentoside A (EsA) possesses anti-inflammatory activity in acute and chronic experimental models[2], has selective inhibitory activity towards cyclooxygenase-2 (COX-2)[1].Esculentoside A (EsA) suppresses inflammatory responses in LPS-induced acute lung injury (ALI) through inhibition of the nuclear factor kappa B (NF-ΚB) and mitogen activated protein kinase (MAPK) signaling pathways[3]. |
| In Vitro | Esculentoside A (0-10 μM; 24 hours) reduced the release of TNF concentration in primed macrophages [4]. |
| In Vivo | Esculentoside A (EsA) (intraperitoneal injection; 20 mg/kg; once a day; 4 weeks) plays significant roles in the treatment of BXSB mice through modulation of inflammatory cytokines, inhibition of renal cell proliferation and induction of apoptosis [2]. Esculentoside A (EsA) (injected intraperitoneally; 5, 10 and 20 mg/kg; once a day; 7 days) dose-dependently decreases the TNF, IL-1 and IL-6 levels in the sera of mice following LPS challenge[4]. Animal Model: BXSB mice[2] Dosage: 20 mg/kg Administration: Intraperitoneal injection; 20 mg/kg; once a day; 4 weeks Result: Alleviated the renal damage of LN. |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 935.8±65.0 °C at 760 mmHg |
| Flash Point | 275.1±27.8 °C |
| Exact Mass | 826.435059 |
| PSA | 262.36000 |
| LogP | 3.01 |
| Vapour Pressure | 0.0±0.6 mmHg at 25°C |