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Glochidiol
| Product Name | Glochidiol |
| Price: | Inquiry |
| Catalog No.: | CN07878 |
| CAS No.: | 6610-56-6 |
| Molecular Formula: | C30H50O2 |
| Molecular Weight: | 442.7 g/mol |
| Purity: | >=98% |
| Type of Compound: | Triterpenoids |
| Physical Desc.: | Powder |
| Source: | The herbs of Glochidion puberum L. |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: |
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| Description | Glochidiol is an orally active tubulin polymerization inhibitor with an IC50 of 2.76 μM. Glochidiol shows anti-cancer activity[1]. |
| Target | IC50: 2.76 μΜ (tubulin polymerization)[1] |
| In Vitro | Glochidiol (1-8 μM; 48 h) 对肺癌细胞系显示出强效的抗增殖活性，且呈浓度依赖性[1]。 Glochidiol 通过靶向秋水仙碱结合位点与微管蛋白相互作用[1]。 Cell Proliferation Assay[1] Cell Line: NCI-H2087, HOP-62, NCI-H520, HCC-44, HARA, EPLC-272H, NCI-H3122, COR-L105 and Calu-6 Concentration: 1, 2, 4 and 8 μM Incubation Time: 48 h Result: Showed potent antiproliferative activity against lung cancer cell lines NCI-H2087, HOP-62, NCI-H520, HCC-44, HARA, EPLC-272H, NCI-H3122, COR-L105 and Calu-6 with IC50 values of 4.12 µM, 2.01 µM, 7.53 µM, 1.62 µM, 4.79 µM, 7.69 µM, 2.36 µM, 6.07 µM and 2.10 µM, respectively. |
| In Vivo | Glochidiol (60 mg/kg/day; i.g.; 21 days) 在裸鼠中有效抑制肺癌 HCC-44 异种移植瘤生长[1]。 Animal Model: BALB/c nude mice bearing HCC-44 xenografts[1] Dosage: 60 mg/kg/day Administration: Intragastric administration for a period of 21 days Result: Decreased average tumor weight and relative tumor volume with no obvious cytotoxic effect on the major organs, including heart, liver, and kidney. |
| Density | 1.0±0.1 g/cm3 |
| Boiling Point | 518.1±50.0 °C at 760 mmHg |
| Flash Point | 208.7±24.7 °C |
| Exact Mass | 442.381073 |
| PSA | 40.46000 |
| LogP | 9.35 |
| Vapour Pressure | 0.0±3.1 mmHg at 25°C |