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Hirsutine
| Product Name | Hirsutine |
| Price: | $141 / 5mg |
| Catalog No.: | CN01093 |
| CAS No.: | 7729-23-9 |
| Molecular Formula: | C22H28N2O3 |
| Molecular Weight: | 368.47 g/mol |
| Purity: | >=98% |
| Type of Compound: | Alkaloids |
| Physical Desc.: | Powder |
| Source: | The herbs of Uncaria rhynchophylla |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | COC=C(C1CC2N(CC1CC)CCc1c2[nH]c2c1cccc2)C(=O)OC |
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| Description | Hirsutine, an indole alkaloid of Uncaria rhynchophylla, exhibits anti-cancer activity. Hirsutine induces apoptosis and is a potent Dengue virus inhibitor exhibiting low cytotoxicity[1][2][3]. |
| In Vitro | Hirsutine remarkably reduces the viability of MCF-7 and MDA-MB-231 cells in a time- and dose-dependent manner with IC50 values of 447.79 and 179.06 μM, respectively. In the MDA-MB-231 cells, Hirsutine induces apoptosis and depolarization of MMP, releases Cyt C from mitochondria, and activates caspase 9 and caspase 3[2]. |
| In Vivo | Hirsutine induces mPTP-dependent apoptosis through ROCK1/PTEN/PI3K/GSK3β pathway in human lung cancer cells[3]. |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 531.7±50.0 °C at 760 mmHg |
| Flash Point | 275.4±30.1 °C |
| Exact Mass | 368.209991 |
| PSA | 54.56000 |
| LogP | 3.96 |
| Vapour Pressure | 0.0±1.4 mmHg at 25°C |