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Cycloastragenol
| Product Name | Cycloastragenol |
| Price: | $46 / 20mg |
| Catalog No.: | CN08103 |
| CAS No.: | 84605-18-5 |
| Molecular Formula: | C30H50O5 |
| Molecular Weight: | 490.71 g/mol |
| Purity: | >=98% |
| Type of Compound: | Triterpenoids |
| Physical Desc.: | Powder |
| Source: | The roots of Astragalus membranaceus (Fisch.) Bunge |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | O[C@H]1C[C@@]2([C@]([C@H]1[C@]1(C)CC[C@@H](O1)C(O)(C)C)(C)CC[C@@]13[C@H]2C[C@H](O)[C@@H]2[C@]3(C1)CC[C@@H](C2(C)C)O)C |
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| Description | Cycloastragenol, a natural tetracyclic triterpenoid, was first identified when screening Astragalus membranaceus extracts for active ingredients with antiaging properties. IC50 value:Target:In vitro: In the study of Cycloastragenolon the treatment of degenerative diseases, the result showed that first-pass intestinal metabolism of cycloastragenol might occur upon passage through the intestinal epithelium. Cycloastragenol underwent extensive metabolism in rat and human liver microsomes with only 17.4% and 8.2%, respectively, of the starting amount of Cycloastragenol remaining after 30 min of incubation [1]. The present study demonstrates that cycloastragenol stimulates telomerase activity and cell proliferation in human neonatal keratinocytes. In particular, cycloastragenol promotes scratch wound closure of human neonatal keratinocyte monolayers in vitro [3]. In vivo: Rats were treated with Cycloastragenol (40 mg·kg- 1·d- 1) for 7 days to induce hepatic microsomal enzyme. The result showed that compared with the control, cycloastragenol obviously activated CYP2E1, and remarkably inhibited CYP3A4 [2]. |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 617.2±55.0 °C at 760 mmHg |
| Flash Point | 327.1±31.5 °C |
| Exact Mass | 490.365814 |
| PSA | 90.15000 |
| LogP | 3.82 |
| Vapour Pressure | 0.0±4.0 mmHg at 25°C |
| Storage condition | -20°C |