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Anemosapogenin
| Product Name | Anemosapogenin |
| Price: | $131 / 10mg |
| Catalog No.: | CN07777 |
| CAS No.: | 85999-40-2 |
| Molecular Formula: | C30H48O4 |
| Molecular Weight: | 472.71 g/mol |
| Purity: | >=98% |
| Type of Compound: | Triterpenoids |
| Physical Desc.: | White cryst. |
| Source: | The branches of Platanus acerifolia |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | OC[C@]1(C)[C@@H](O)CC[C@]2([C@H]1CC[C@@]1([C@@H]2CC[C@H]2[C@@]1(C)CC[C@@]1([C@@H]2[C@@H](CC1)C(=C)C)C(=O)O)C)C |
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| Description | 23-hydroxybetulinic acid is one of the bioactive components responsible for its anticancer activity.In vitro: 23-hydroxybetulinic acid also shows different proliferation inhibitory activity against B16, HeLa, and HUVEC, with the IC50 value of 78.5, 80, and 94.8 uM, respectively. 23-hydroxybetulinic acid can promote cell cycle arrest at S phase and induce apoptosis via intrinsic pathway. 23-hydroxybetulinic acid disrupts mitochondrial membrane potential significantly (p<0.01) and selectively downregulates the levels of Bcl-2, survivin and upregulates Bax, cytochrome C, cleaved caspase-9 23-hydroxybetulinic acid can induce apoptosis in K562 cells. [1] 23-hydroxybetulinic acid enhances sensitivity of doxorubicin (DOX, ADR) on MCF-7/ADR cell lines, indicating its potential to be developed as a novel MDR modulator.[2] 23-HBA significantly improve the sensitivity of the tumor to doxorubicin. [3] |
| Density | 1.1±0.1 g/cm3 |
| Boiling Point | 585.8±25.0 °C at 760 mmHg |
| Flash Point | 322.1±19.7 °C |
| Exact Mass | 472.355255 |
| PSA | 77.76000 |
| LogP | 7.29 |
| Vapour Pressure | 0.0±3.7 mmHg at 25°C |